Wednesday, 27 February 2013

Revisit the Archives

An article from way back when in 2007 on cellular autophagy!  Episodic calorie restriction (think intermittent fasting rather than chronic caloric restriction) *may* be of increasing importance as we age:
  • “Cell survival is dependent upon the ability of the cell to reduce and recycle by a mechanism called autophagy,” said William Dunn Jr., a professor of anatomy and cell biology in UF’s College of Medicine and senior author of the study, which was published online this month in the journal Rejuvenation Research. “When a cell is under stress, autophagy is turned on to clean up the cell by removing damaged cellular components, while recycling building blocks necessary to rebuild the cell. It’s there to protect the cell. But in aged cells, they’re basically not able to adjust to stress as well.”

    UF scientists studied 22 young and old rats, comparing those allowed to eat freely with those fed a low-calorie, nutritious diet. The stress of a low-calorie diet was enough to boost cellular cleaning in the hearts of older rats by 120 percent over levels seen in rats that were allowed to eat what they wanted. The diet had little or no effect on younger rats.
     
The accumulation of damage litters the road to morbidity.

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