In reading about these two drug classes, most of the trials that I have seen referred to seem to be trialed for a very limited period - downwards of five years. This is fine unless you are going to be taking these drugs for longer than five years - where suddenly you become a 'pioneer test subject'.
Let me add that there are good reasons to listen to your doctor's advice and I am woefully unqualified to give medical advice - but hell, I would rather die of an illness rather than pay to die of chronic poisoning.
The Indian Times report on research undertaken by Dr Mark Hamer, Senior Research Fellow in the Department of Epidemiology and Public Health at UCL and his colleagues used data from the Scottish Health Survey, who found that tricyclic anti-depressants were associated with a 35% increased risk of CVD:
- "Our findings suggest that there is an association between the use of tricyclic anti-depressants and an increased risk of CVD that is not explained by existing mental illness," Hamer said.
"This suggests that there may be some characteristic of tricyclics that is raising the risk. Tricyclics are known to have a number of side effects; they are linked to increased blood pressure, weight gain and diabetes and these are all risk factors for CVD," he said.